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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC6
All Species:
32.42
Human Site:
S735
Identified Species:
64.85
UniProt:
Q96SB8
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SB8
NP_001135758.1
1091
126326
S735
E
N
I
E
E
H
Q
S
V
D
I
A
T
L
E
Chimpanzee
Pan troglodytes
XP_001136387
1091
126280
S735
E
N
I
E
E
H
Q
S
V
D
I
A
T
L
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532882
1606
180795
S1250
E
N
I
E
E
H
Q
S
V
D
I
A
T
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q924W5
1097
127179
S741
E
N
I
E
E
H
Q
S
V
D
I
A
T
L
E
Rat
Rattus norvegicus
NP_001101484
1097
127259
S741
E
N
I
E
E
H
Q
S
V
D
I
A
T
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505822
579
67328
I249
K
L
E
R
Q
R
K
I
F
Q
L
K
E
K
S
Chicken
Gallus gallus
XP_419962
1096
127736
Y742
E
N
V
D
E
I
Q
Y
M
D
I
R
V
L
E
Frog
Xenopus laevis
Q6P9I7
1128
130494
S773
E
N
V
E
E
Q
P
S
I
D
I
A
T
L
E
Zebra Danio
Brachydanio rerio
NP_001121806
1090
126266
S740
Q
N
V
E
E
P
Q
S
E
D
L
K
P
L
E
Tiger Blowfish
Takifugu rubipres
Q802R8
1090
124790
S741
K
N
V
E
E
P
Q
S
E
D
L
A
E
L
K
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794820
1236
142110
I854
R
G
D
T
D
N
E
I
S
E
T
K
R
D
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12749
1114
127990
K755
N
F
R
M
T
E
L
K
M
N
V
G
K
V
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
63.3
N.A.
90
90.4
N.A.
38.1
59.7
60.5
51.4
45.9
N.A.
N.A.
N.A.
30.2
Protein Similarity:
100
100
N.A.
66.1
N.A.
96.3
96.2
N.A.
44
77.9
76.7
70.3
67
N.A.
N.A.
N.A.
50.9
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
0
53.3
73.3
53.3
53.3
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
26.6
73.3
86.6
73.3
80
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
59
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
9
9
0
0
0
0
75
0
0
0
9
0
% D
% Glu:
59
0
9
67
75
9
9
0
17
9
0
0
17
0
67
% E
% Phe:
0
9
0
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% G
% His:
0
0
0
0
0
42
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
42
0
0
9
0
17
9
0
59
0
0
0
0
% I
% Lys:
17
0
0
0
0
0
9
9
0
0
0
25
9
9
9
% K
% Leu:
0
9
0
0
0
0
9
0
0
0
25
0
0
75
0
% L
% Met:
0
0
0
9
0
0
0
0
17
0
0
0
0
0
9
% M
% Asn:
9
75
0
0
0
9
0
0
0
9
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
17
9
0
0
0
0
0
9
0
0
% P
% Gln:
9
0
0
0
9
9
67
0
0
9
0
0
0
0
0
% Q
% Arg:
9
0
9
9
0
9
0
0
0
0
0
9
9
0
0
% R
% Ser:
0
0
0
0
0
0
0
67
9
0
0
0
0
0
9
% S
% Thr:
0
0
0
9
9
0
0
0
0
0
9
0
50
0
0
% T
% Val:
0
0
34
0
0
0
0
0
42
0
9
0
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _